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Un nouveau traitement s’est avéré très prometteur contre la maladie de Crohn et la rectocolite hémorragique, des inflammations intestinales chroniques invalidantes, selon deux essais cliniques internationaux publiés mercredi aux États-Unis. Cette nouvelle molécule, le vedolizumab du laboratoire japonais Takeda, offre un nouvel espoir aux quatre millions de personnes atteintes de l’une ou l’autre de ces pathologies auto-immunes, estiment les chercheurs qui ont mené ces études cliniques parues dans le New England Journal of Medicine. Ces essais cliniques de phase 3, conduits dans 39 pays, auxquels ont participé quelque 3000 personnes, «ont montré des résultats très encourageants pour des malades souffrant de la maladie de Crohn et de rectocolite hémorragique pour qui les traitements conventionnels, comme les stéroïdes ou des suppresseurs du système immunitaire, sont inefficaces», explique le Dr William Sandborn, directeur du centre des maladies inflammatoires intestinales à l’Université de Californie à San Diego, qui a mené l’étude sur la maladie de Crohn. Cet anticorps, administré par intraveineuse, cible des cellules immunitaires dans l’intestin qui libèrent des protéines (cytokines) responsables de l’inflammation qui endommage les tissus du gros et petit intestins et provoque des diarrhées. Ce traitement est très ciblé, ce qui limite le risque d’effets secondaires alors que les traitements traditionnels s’accompagnent d’effets secondaires comme la perte de poids, les nausées et les maux de tête, soulignent les chercheurs, sustanon plus deca.
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